TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication
SARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of
viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in …
viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in …
Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication
CA Rodríguez-Salazar, S van Tol, O Mailhot… - PLoS …, 2024 - journals.plos.org
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe
hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase …
hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase …
[HTML][HTML] Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication creating new therapeutic opportunities
CA Rodríguez-Salazar, S van Tol, O Mailhot, G Galdino… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Ebolavirus (EBOV) belongs to a family of highly pathogenic viruses that cause severe
hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase …
hemorrhagic fever in humans. EBOV replication requires the activity of the viral polymerase …
Understanding and Predicting Ligand Efficacy in the μ-Opioid Receptor through Quantitative Dynamical Analysis of Complex Structures
GT Galdino, O Mailhot… - Journal of Chemical …, 2024 - ACS Publications
The μ-opioid receptor (MOR) is a G-protein coupled receptor involved in nociception and the
primary target of opioid drugs. Understanding the relationships among the ligand structure …
primary target of opioid drugs. Understanding the relationships among the ligand structure …
ProCogGraph: a graph-based mapping of cognate ligand domain interactions
Motivation Mappings of domain-cognate ligand interactions can enhance our understanding
of the core concepts of evolution and be used to aid docking and protein design. Since the …
of the core concepts of evolution and be used to aid docking and protein design. Since the …
Comprehensive Analysis of SARS-CoV-2 Spike Evolution: Epitope Classification and Immune Escape Prediction
The evolution of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has
produced unprecedented numbers of structures of the Spike protein. This study presents a …
produced unprecedented numbers of structures of the Spike protein. This study presents a …
How do we respond to the next SARS CoV epidemic/pandemic? A bioinformatics approach with the promise of preventing or reducing the severity of future SARS CoV …
B Geoffrey AS, J Gracia - bioRxiv, 2024 - biorxiv.org
In this work, we develop a Bayesian weighted scheme to generate evolutionary lineages of
a particular viral protein sequence of interest and through a process of clustering and …
a particular viral protein sequence of interest and through a process of clustering and …
Molecular Glue-Design-Evaluator (MOLDE): An Advanced Method for In-Silico Molecular Glue Design
Protein function modulation using small molecule binding is an important therapeutic
strategy for many diseases. However, many proteins remain undruggable due to lack of …
strategy for many diseases. However, many proteins remain undruggable due to lack of …