Turning'sweet'on immunity: galectin–glycan interactions in immune tolerance and inflammation

GA Rabinovich, MA Toscano - Nature Reviews Immunology, 2009 - nature.com
The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

Galectins: structure, function and therapeutic potential

RY Yang, GA Rabinovich, FT Liu - Expert reviews in molecular …, 2008 - cambridge.org
Galectins are a family of animal lectins that bind β-galactosides. Outside the cell, galectins
bind to cell-surface and extracellular matrix glycans and thereby affect a variety of cellular …

Regulation of transforming growth factor-β1–driven lung fibrosis by galectin-3

AC MacKinnon, MA Gibbons, SL Farnworth… - American journal of …, 2012 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar
epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting …

Galectin-1: a small protein with major functions

I Camby, M Le Mercier, F Lefranc, R Kiss - Glycobiology, 2006 - academic.oup.com
Galectins are a family of carbohydrate-binding proteins with an affinity for β-galactosides.
Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and …

Galectins: regulators of acute and chronic inflammation

FT Liu, GA Rabinovich - Annals of the New York Academy of …, 2010 - Wiley Online Library
Galectins, β‐galactoside‐binding animal lectins, are differentially expressed by various
immune cells as well as a wide range of other cell types. Extracellularly, galectins are able to …

Galectins and immune responses—just how do they do those things they do?

S Thiemann, LG Baum - Annual review of immunology, 2016 - annualreviews.org
Galectins are a family of mammalian carbohydrate-binding proteins expressed by many cell
types. Galectins can function intracellularly and can also be secreted to bind to cell surface …

Animal lectins: a historical introduction and overview

DC Kilpatrick - Biochimica et biophysica acta (BBA)-General subjects, 2002 - Elsevier
Some proteins we now regard as animal lectins were discovered before plant lectins, though
many were not recognised as carbohydrate-binding proteins for many years after first being …

Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?

GA Rabinovich, LG Baum, N Tinari, R Paganelli… - Trends in …, 2002 - cell.com
Recent evidence has implicated galectins and their ligands as master regulators of immune
cell homeostasis. Whereas some members of this family, such as galectin-3, behave as …

[图书][B] Lectins

N Sharon, H Lis - 2003 - books.google.com
This is the second edition of our little red book Lectins published in 1989. In the intervening
years well over 10,000 articles have appeared with lectins as the main subject, and more …

The role of galectins as modulators of metabolism and inflammation

MF Brinchmann, DM Patel… - Mediators of …, 2018 - Wiley Online Library
Galectins are β‐galcotosid‐binding lectins. The function of galectins varies with their tissue‐
specific and subcellular location, and their binding to carbohydrates makes them key players …