[PDF][PDF] HIV-1 vaccines based on antibody identification, B cell ontogeny, and epitope structure
PD Kwong, JR Mascola - Immunity, 2018 - cell.com
HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …
Broadly neutralizing antibodies to HIV and their role in vaccine design
DR Burton, L Hangartner - Annual review of immunology, 2016 - annualreviews.org
HIV employs multiple means to evade the humoral immune response, particularly the
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
elicitation of and recognition by broadly neutralizing antibodies (bnAbs). Such antibodies …
[PDF][PDF] High-throughput mapping of B cell receptor sequences to antigen specificity
I Setliff, AR Shiakolas, KA Pilewski, AA Murji… - Cell, 2019 - cell.com
B cell receptor (BCR) sequencing is a powerful tool for interrogating immune responses to
infection and vaccination, but it provides limited information about the antigen specificity of …
infection and vaccination, but it provides limited information about the antigen specificity of …
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
L Xu, A Pegu, E Rao, N Doria-Rose, J Beninga… - Science, 2017 - science.org
The development of an effective AIDS vaccine has been challenging because of viral
genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We …
genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We …
[PDF][PDF] Identification of a CD4-binding-site antibody to HIV that evolved near-pan neutralization breadth
Detailed studies of the broadly neutralizing antibodies (bNAbs) that underlie the best
available examples of the humoral immune response to HIV are providing important …
available examples of the humoral immune response to HIV are providing important …
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
A major goal of HIV-1 vaccine research is the design of immunogens capable of inducing
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …
broadly neutralizing antibodies (bnAbs) that bind to the viral envelope glycoprotein (Env) …
[PDF][PDF] Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice
A vaccine that elicits broadly neutralizing antibodies (bNAbs) against HIV-1 is likely to be
protective, but this has not been achieved. To explore immunization regimens that might …
protective, but this has not been achieved. To explore immunization regimens that might …
[PDF][PDF] Structural repertoire of HIV-1-neutralizing antibodies targeting the CD4 supersite in 14 donors
The site on the HIV-1 gp120 glycoprotein that binds the CD4 receptor is recognized by
broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To …
broadly reactive antibodies, several of which neutralize over 90% of HIV-1 strains. To …
Observed antibody space: a resource for data mining next-generation sequencing of antibody repertoires
Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …
sequence diversity and binding versatility have made Abs the primary class of …
[PDF][PDF] Immunization for HIV-1 broadly neutralizing antibodies in human Ig knockin mice
A subset of individuals infected with HIV-1 develops broadly neutralizing antibodies (bNAbs)
that can prevent infection, but it has not yet been possible to elicit these antibodies by …
that can prevent infection, but it has not yet been possible to elicit these antibodies by …