Promising therapeutic targets for treatment of rheumatoid arthritis

J Huang, X Fu, X Chen, Z Li, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

[HTML][HTML] Role of Th22 cells in the pathogenesis of autoimmune diseases

Q Jiang, G Yang, F Xiao, J Xie, S Wang, L Lu… - Frontiers in …, 2021 - frontiersin.org
Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …

Quercetin-mediated SIRT1 activation attenuates collagen-induced mice arthritis

P Shen, W Lin, X Ba, Y Huang, Z Chen, L Han… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Herba taxilli (HT, Sangjisheng in Chinese), which is
composed of the dried stems and leaves of Taxillus chinensis (DC.) Danser, has been …

[HTML][HTML] Chemokines and chemokine receptors as promising targets in rheumatoid arthritis

MA Murayama, J Shimizu, C Miyabe, K Yudo… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Effects of poor sleep on the immune cell landscape as assessed by single-cell analysis

X Liu, B Chen, Z Huang, R Duan, H Li, L Xie… - Communications …, 2021 - nature.com
Poor sleep has become an important public health issue. With loss of sleep durations, poor
sleep has been linked to the increased risks for diseases. Here we employed mass …

Th1 chemokines in autoimmune endocrine disorders

P Fallahi, SM Ferrari, F Ragusa, I Ruffilli… - The Journal of …, 2020 - academic.oup.com
Context The CXC chemokine receptor CXCR3 and its chemokines CXCL10, CXCL9, and
CXCL11 are implicated in the pathogenesis of autoimmune diseases. Here, we review these …

Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways

Y Shen, L Teng, Y Qu, J Liu, X Zhu, S Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance The dried aboveground part of Geranium Wilfordii
Maxim.(G. Wilfordii) is a traditional Chinese herbal medicine named lao-guan-cao. It has …

Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed …

Y Zhang, J Chen, H Fu, S Kuang, F He… - International journal of …, 2021 - nature.com
Although mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to have
therapeutic effects in experimental periodontitis, their drawbacks, such as low yield and …

Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma-Smilax glabra Roxb herb pair for the …

XQ Hu, C Qi, F Feng, Y Wang, TT Di, YJ Meng, Y Wang… - Phytomedicine, 2022 - Elsevier
Background Psoriasis is a prevalent chronic inflammatory skin condition marked by immune
cell infiltration and keratinocyte abnormal proliferation. Cimicifugae Rhizoma-Smilax glabra …

Chemokine receptor 5 antagonism causes reduction in joint inflammation in a collagen-induced arthritis mouse model

MA Ansari, A Nadeem, SA Bakheet, SM Attia, M Shahid… - Molecules, 2021 - mdpi.com
Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly affecting the synovial
joints. A highly potent antagonist of CC chemokine receptor 5 (CCR5), maraviroc (MVC) …