Deep-lipidotyping by mass spectrometry: recent technical advances and applications

W Zhang, R Jian, J Zhao, Y Liu, Y Xia - Journal of Lipid Research, 2022 - ASBMB
In-depth structural characterization of lipids is an essential component of lipidomics. There
has been a rapid expansion of mass spectrometry methods that are capable of resolving …

Ion mobility mass spectrometry for the separation and characterization of small molecules

L Liu, Z Wang, Q Zhang, Y Mei, L Li, H Liu… - Analytical …, 2023 - ACS Publications
Small molecules with molecular weights less than 1500 Da represented by natural
metabolites such as amino acids, nucleotides, carbohydrates, lipids, flavonoids, alkaloids …

High-confidence structural identification of metabolites relying on tandem mass spectrometry through isomeric identification: A tutorial

Y Song, Q Song, W Liu, J Li, P Tu - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
MS/MS currently serves as the workhorse for metabolomics. Structural identification is
extremely important to correlate statistical variables to biochemical functions and …

Different ion mobility‐mass spectrometry coupling techniques to promote metabolomics

A Delvaux, E Rathahao‐Paris… - Mass Spectrometry …, 2022 - Wiley Online Library
Metabolomics has become increasingly popular in recent years for many applications
ranging from clinical diagnosis, human health to biotechnological questioning. Despite …

Perspective on emerging mass spectrometry technologies for comprehensive lipid structural elucidation

JR Bonney, BM Prentice - Analytical chemistry, 2021 - ACS Publications
Lipids and metabolites are of interest in many clinical and research settings because it is the
metabolome that is increasingly recognized as a more dynamic and sensitive molecular …

High-resolution demultiplexing (HRdm) ion mobility spectrometry–mass spectrometry for aspartic and isoaspartic acid determination and screening

KE Butler, JN Dodds, T Flick, IDG Campuzano… - Analytical …, 2022 - ACS Publications
Isomeric peptide analyses are an analytical challenge of great importance to therapeutic
monoclonal antibody and other biotherapeutic product development workflows. Aspartic …

Chiral derivatization-enabled discrimination and on-tissue detection of proteinogenic amino acids by ion mobility mass spectrometry

C Xie, Y Chen, X Wang, Y Song, Y Shen, X Diao… - Chemical …, 2022 - pubs.rsc.org
The importance of chiral amino acids (AAs) in living organisms has been widely recognized
since the discovery of endogenous D-AAs as potential biomarkers in several metabolic …

Quantification of biocatalytic transformations by single microbial cells enabled by tailored integration of droplet microfluidics and mass spectrometry

K Wink, M van Der Loh, N Hartner… - Angewandte Chemie …, 2022 - Wiley Online Library
Improving the performance of chemical transformations catalysed by microbial biocatalysts
requires a deep understanding of cellular processes. While the cellular heterogeneity of …

Algorithms for de-novo sequencing of peptides by tandem mass spectrometry: A review

CCA Ng, Y Zhou, ZP Yao - Analytica Chimica Acta, 2023 - Elsevier
Peptide sequencing is of great significance to fundamental and applied research in the
fields such as chemical, biological, medicinal and pharmaceutical sciences. With the rapid …

Advanced mass spectrometric and spectroscopic methods coupled with machine learning for in vitro diagnosis

X Chen, W Shu, L Zhao, J Wan - View, 2023 - Wiley Online Library
In vitro diagnosis (IVD) is one vital component of medical tests that detects biological
samples of tissues or bio‐fluids. Recently, mass spectrometry and spectroscopy have been …