In eukaryotic cells, the DNA molecule is found in the form of a nucleoprotein complex named
chromatin. The basic unit of the chromatin is the nucleosome, which comprises 147 base …

Protein ubiquitination is an important post-translational modification that regulates almost
every aspect of cellular function and many cell signaling pathways in eukaryotes. Alterations …

Chemical derivatisation of functional groups has proved popular since the beginning of
organic mass spectrometry as a means to enhance the stability and volatility of the analytes …

The mechanisms by which ubiquitin ligases are regulated remain poorly understood. Here
we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective …

RING (really interesting new gene) and U-box E3 ligases bridge E2 ubiquitin-conjugating
enzymes and substrates to enable the transfer of ubiquitin to a lysine residue on the …

Available amino acids are those absorbed from the gastrointestinal tract in a form suitable
for body protein synthesis. True ileal digestible amino acids are determined based on the …

The transfer of ubiquitin (Ub) to a substrate protein requires a cascade of E1 activating, E2
conjugating, and E3 ligating enzymes. E3 Ub ligases containing U-box and RING domains …

Ultraviolet photodissociation (UVPD) of chromophore-modified peptides enhances the
capabilities for de novo sequencing in a quadrupole ion trap mass spectrometer. Attachment …

The dimeric E3 ubiquitin ligase CHIP binds with its tetratricopeptide repeat (TPR) domain
the C-terminus of molecular chaperones Hsp70 and Hsp90 and with its U-box region E2 …

Post‐translational modifications of proteins including phosphorylation, glycosylation,
acetylation and ubiquitination facilitate the regulation of many cellular processes and …