[HTML][HTML] Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging
K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …
[HTML][HTML] The NLRP3 inflammasome pathway: A review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
[HTML][HTML] Applications of phyto-nanotechnology for the treatment of neurodegenerative disorders
The strategies involved in the development of therapeutics for neurodegenerative disorders
are very complex and challenging due to the existence of the blood-brain barrier (BBB), a …
are very complex and challenging due to the existence of the blood-brain barrier (BBB), a …
[HTML][HTML] Amyloid beta and phosphorylated tau-induced defective autophagy and mitophagy in Alzheimer's disease
PH Reddy, DMA Oliver - Cells, 2019 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
memory loss and multiple cognitive impairments. Several decades of intense research have …
memory loss and multiple cognitive impairments. Several decades of intense research have …
[HTML][HTML] Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
C Simioni, G Zauli, AM Martelli, M Vitale, G Sacchetti… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is
nowadays seen as an indispensable element for good health, able to lower the risk of …
nowadays seen as an indispensable element for good health, able to lower the risk of …
[HTML][HTML] Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics
Among the major neurodegenerative disorders (NDDs), Alzheimer's disease (AD) and
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …
Parkinson's disease (PD), are a huge socioeconomic burden. Over many centuries, people …
[HTML][HTML] Pathophysiology and treatment of cerebral edema in traumatic brain injury
RM Jha, PM Kochanek, JM Simard - Neuropharmacology, 2019 - Elsevier
Cerebral edema (CE) and resultant intracranial hypertension are associated with
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …
unfavorable prognosis in traumatic brain injury (TBI). CE is a leading cause of in-hospital …
[HTML][HTML] Potential role of ginger (Zingiber officinale Roscoe) in the prevention of neurodegenerative diseases
Ginger is composed of multiple bioactive compounds, including 6-gingerol, 6-shogaol, 10-
gingerol, gingerdiones, gingerdiols, paradols, 6-dehydrogingerols, 5-acetoxy-6-gingerol, 3 …
gingerol, gingerdiones, gingerdiols, paradols, 6-dehydrogingerols, 5-acetoxy-6-gingerol, 3 …
[HTML][HTML] Pathobiology of the klotho antiaging protein and therapeutic considerations
GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …
Role of reactive oxygen species in the progression of Alzheimer's disease
Highlights•Oxidative stress is an etiopathogenic event upstream to Aβ-plaques and
neurofibrillary tangles leading to Alzheimer's disease.•Unquenched ROS perturb the …
neurofibrillary tangles leading to Alzheimer's disease.•Unquenched ROS perturb the …