Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Reactive oxygen species (ROS) are produced during oxidative metabolism in aerobic
organisms. Under normal conditions, ROS production and elimination are in a relatively …

The SARS-CoV-2 beta coronavirus is the etiological driver of COVID-19 disease, which is
primarily characterized by shortness of breath, persistent dry cough, and fever. Because they …

Metabolomics has emerged in the past decade as a highly attractive and impactful
technique for phenotype-level profiling in diverse biological applications. Most recently, the …

Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Red blood cells (RBCs) units are the most requested transfusion product worldwide.
Indications for transfusion include symptomatic anaemia, acute sickle cell crisis, and acute …

Red blood cell (RBC) storage in the blood bank promotes the progressive accumulation of
metabolic alterations that may ultimately impact the erythrocyte capacity to cope with oxidant …

COVID-19 is a global pandemic triggered by the severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 entry point involves the interaction with …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass …

Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and,
most importantly, hydrogen peroxide. However, it is unclear whether accumulation of …