The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple
synthetic solutions, especially when the creation of chiral centers is involved. Historically …

The rich legacy of arenediazonium salts in the synthesis of unsymmetrical biaryls, built
around the seminal works of Pschorr, Gomberg and Bachmann more than a century ago …

The widespread success of BINOL-chiral phosphoric acids (CPAs) has led to the
development of several high molecular weight, sterically encumbered variants. Herein, we …

The standard proteinogenic amino acids grant access to a myriad of chemistries that
harmonize to create life. Outside of these twenty canonical protein building blocks are …

Unnatural amino acids have gained significant attention in protein engineering and drug
discovery as they allow the evolution of proteins with enhanced stability and activity. The …

Aryl fluorosulfates are versatile building blocks in organic synthesis and have gained
increasing attention in SuFEx (Sulfur Fluoride Exchange) click chemistry. They are easily …

A novel synthetic route for making (−)-CBD and its derivatives bearing various C4′-side
chains is developed by a late-stage diversification method. Starting from commercially …

Cross-coupling reactions have played a key role in producing numerous types of π-
conjugated small molecules having appealing properties for practical applications in organic …

The use of enzymes has become increasingly widespread in synthesis as chemists strive to
reduce their reliance on organic solvents in favor of more environmentally benign aqueous …

TRPM8 has recently emerged as a druggable target in prostate cancer (PC) and TRPM8
modulators have been proposed as potential anticancer agents in this pathology. We have …