The rise in antimicrobial resistant bacteria threatens the current methods utilized to treat
bacterial infections. The development of novel therapeutic agents is crucial in avoiding a …

Cathelicidins are host defense peptides with antimicrobial and immunomodulatory functions.
These effector molecules of the innate immune system of many vertebrates are diverse in …

Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell
membrane during the cell death program pyroptosis. GSDMs are activated by proteolytic …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

“Strep throat” is highly prevalent among children, yet it is unknown why only some children
develop recurrent tonsillitis (RT), a common indication for tonsillectomy. To gain insights into …

Group A Streptococcus (GAS; Streptococcus pyogenes) is a nearly ubiquitous human
pathogen responsible for a significant global disease burden. No vaccine exists, so …

Interleukin-1β (IL-1β) is a key proinflammatory cytokine that drives antimicrobial immune
responses. IL-1β is aberrantly activated in autoimmune diseases, and IL-1β inhibitors are …

Covering: up to 2018 Antimicrobial peptides (AMPs) have been known for well over three
decades as crucial mediators of the innate immune response in animals and plants, where …

The release of neutrophil extracellular traps (NETs) is a major immune mechanism intended
to capture pathogens. These histone-and protease-coated DNA structures are released by …

In the ongoing conflict between eukaryotic cells and pathogens, lipid droplets (LDs) emerge
as a choke point in the battle for nutrients. While many pathogens seek the lipids stored in …