Pullulan, a natural polysaccharide with unique biocompatibility and biodegradability, has
gained prominence in nanomedicine. Its application in nanoparticle drug delivery systems …

Drug amorphization is one of the major approaches in pharmaceutical sciences to improve
the solubility and dissolution rate of poorly water-soluble drugs. Amorphous solid …

To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five
novel solid forms in 1: 1 stoichiometry were obtained upon liquid-assisted grinding, slurry …

Cocrystals are recognized as one of the most efficient approaches to improve aqueous
solubility of Biopharmaceutical Classification System, BCS, classes II and IV drugs …

Objective: This study aims to synthesize acetylsalicylic acid (ASA) cocrystals using valine as
a coformer via a co-crystallization technique to increase the solubility and dissolution rate of …

Various drugs are not able to reach the market due to their poor bioavailability and poor
solubility in aqueous media. Hence, several approaches are used to enhance the solubility …

Background: Diabetes mellitus is a chronic metabolic disease, which possibly leads to
kidney, brain, heart failure, and other organ complications, subsequently harming human …

Medicinal plants are increasingly being explored due to their possible pharmacological
properties and minimal adverse effects. However, low bioavailability and stability often limit …

Plant extracts demonstrate significant potential as a rich source of active pharmaceutical
ingredients, exhibiting diverse biological activities and minimal toxicity. However, the low …

Introduction Amorphous drug dispersion is frequently used to enhance the solubility and
dissolution of poorly water-soluble drugs, thereby improving their oral bioavailability. The …