Voltage-gated sodium channels (VGSCs) are responsible for the initiation and propagation
of action potentials in excitable cells. VGSCs in mammalian brain are heterotrimeric …

Voltage-gated sodium channels are protein complexes comprised of one pore forming α
subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β …

Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

More than 300 variants in 12 genes have been associated with Brugada syndrome (BrS)
which has a prevalence ranging between 1: 2000 and 1: 100,000. Until recently, there has …

Background: Brugada syndrome (BrS) is an inherited arrhythmia syndrome caused by loss-
of-function variants in the cardiac sodium channel gene SCN5A (sodium voltage-gated …

Brugada syndrome (BrS) is a clinical entity first described in 1992. BrS is characterized by
ST-segment elevations in the right precordial leads and susceptibility to ventricular …

Cardiac myocyte contraction is initiated by a set of intricately orchestrated electrical
impulses, collectively known as action potentials (APs). Voltage-gated sodium channels …

Both inherited and acquired cardiac arrhythmias are often associated with the abnormal
functional expression of ion channels at the cellular level. The complex machinery that …

The sudden infant death syndrome (SIDS) causes the sudden death of an apparently
healthy infant, which remains unexplained despite a thorough investigation, including the …

Brugada syndrome is characterised by a typical ECG with ST segment elevation in the right
precordial leads. Individuals with this condition are susceptible to ventricular arrhythmias …