Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Chromatin folds into dynamic loops that often span hundreds of kilobases and physically
wire distant loci together for gene regulation. These loops are continuously created …

The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

How chromosome organization is related to genome function remains poorly understood.
Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create …

Conformation capture-approaches like Hi-C can elucidate chromosome structure at a
genome-wide scale. Hi-C datasets are large and require specialised software. Here, we …

Eukaryotic genomes are folded into loops. It is thought that these are formed by cohesin
complexes via extrusion, either until loop expansion is arrested by CTCF or until cohesin is …

The core cohesin subunit STAG2 is recurrently mutated in Ewing sarcoma but its biological
role is less clear. Here, we demonstrate that cohesin complexes containing STAG2 occupy …

Cohesin folds the genome in dynamic chromatin loops and holds the sister chromatids
together. NIPBL Scc2 is currently considered the cohesin loader, a role that may need …

Although often located at a distance from their target gene promoters, enhancers are the
primary genomic determinants of temporal and spatial transcriptional specificity in …

Mutations of the cohesin complex in human cancer were first discovered~ 10 years ago.
Since then, researchers worldwide have demonstrated that cohesin is among the most …