Copper homeostasis and cuproptosis in cardiovascular disease therapeutics

L Yang, P Yang, GYH Lip, J Ren - Trends in pharmacological sciences, 2023 - cell.com
Copper (Cu) homeostasis is gaining increasing attention in human health as both Cu
overload and deficiency evokes pathological changes including cardiovascular diseases …

The molecular mechanisms of defective copper metabolism in diabetic cardiomyopathy

X Cui, Y Wang, H Liu, M Shi, J Wang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

[HTML][HTML] An emerging role of defective copper metabolism in heart disease

Y Liu, J Miao - Nutrients, 2022 - mdpi.com
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Copper and diabetes: current research and prospect

W Chang, P Li - Molecular Nutrition & Food Research, 2023 - Wiley Online Library
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

Behind the link between copper and angiogenesis: established mechanisms and an overview on the role of vascular copper transport systems

E Urso, M Maffia - Journal of vascular research, 2016 - karger.com
Angiogenesis critically sustains the progression of both physiological and pathological
processes. Copper behaves as an obligatory co-factor throughout the angiogenic signalling …

[HTML][HTML] Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice

Y Chen, J Du, YT Zhao, L Zhang, G Lv… - Cardiovascular …, 2015 - Springer
Background Recent evidence indicates that inhibition of histone deacetylase (HDAC)
protects the heart against myocardial injury and stimulates endogenous angiomyogenesis …

[HTML][HTML] General aspects of metal ions as signaling agents in health and disease

K Krzywoszyńska, D Witkowska, J Świątek-Kozłowska… - Biomolecules, 2020 - mdpi.com
This review focuses on the current knowledge on the involvement of metal ions in signaling
processes within the cell, in both physiological and pathological conditions. The first section …

Evidence for widespread, severe brain copper deficiency in Alzheimer's dementia

J Xu, SJ Church, S Patassini, P Begley… - Metallomics, 2017 - academic.oup.com
Datasets comprising simultaneous measurements of many essential metals in Alzheimer's
disease (AD) brain are sparse, and available studies are not entirely in agreement. To …

Is copper a new target to counteract the progression of chronic diseases?

C Balsano, C Porcu, S Sideri - Metallomics, 2018 - academic.oup.com
Altered regulation of copper (Cu) homeostasis may contribute to the development of many
pathologies, such as metabolic, cardiovascular, neurodegenerative and cancerous …

Dissecting copper homeostasis in diabetes mellitus

J Lowe, R Taveira‐da‐Silva, E Hilário‐Souza - Iubmb Life, 2017 - Wiley Online Library
Diabetes Mellitus (DM) is characterized by elevated blood glucose levels (hyperglycemia). It
can occur due to impaired secretion or action of the hormone insulin, which is produced by …