Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves
an alteration in any of the components of the erectile response, including organic, relational …

Nitrogen heterocycles are among the most significant structural components of
pharmaceuticals. Analysis of our database of US FDA approved drugs reveals that 59% of …

CORRESPONDENCE (tool compounds are valuable for achieving the target redundancy
needed to differentiate on-target from off-target activities of clinical drugs being considered …

Identifying new indications for drugs plays an essential role at many phases of drug
research and development. Computational methods are regarded as an effective way to …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …

Material de distribuição exclusiva à classe médica. Os Arquivos Brasileiros de Cardiologia
não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a …

Erectile dysfunction is a common clinical entity that affects mainly men older than 40 years.
In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and …

The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the
treatment of inflammation-based diseases. Several scientific advancements, by both …