Erectile dysfunction
Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves
an alteration in any of the components of the erectile response, including organic, relational …
an alteration in any of the components of the erectile response, including organic, relational …
Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among US FDA approved pharmaceuticals: miniperspective
E Vitaku, DT Smith, JT Njardarson - Journal of medicinal chemistry, 2014 - ACS Publications
Nitrogen heterocycles are among the most significant structural components of
pharmaceuticals. Analysis of our database of US FDA approved drugs reveals that 59% of …
pharmaceuticals. Analysis of our database of US FDA approved drugs reveals that 59% of …
The Drug Repurposing Hub: a next-generation drug library and information resource
SM Corsello, JA Bittker, Z Liu, J Gould, P McCarren… - Nature medicine, 2017 - nature.com
CORRESPONDENCE (tool compounds are valuable for achieving the target redundancy
needed to differentiate on-target from off-target activities of clinical drugs being considered …
needed to differentiate on-target from off-target activities of clinical drugs being considered …
HINGRL: predicting drug–disease associations with graph representation learning on heterogeneous information networks
Identifying new indications for drugs plays an essential role at many phases of drug
research and development. Computational methods are regarded as an effective way to …
research and development. Computational methods are regarded as an effective way to …
Strategies to increase nitric oxide signalling in cardiovascular disease
JO Lundberg, MT Gladwin, E Weitzberg - Nature reviews Drug …, 2015 - nature.com
Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …
[HTML][HTML] Enhancing autophagy in Alzheimer's disease through drug repositioning
Alzheimer's disease (AD) is one of the biggest human health threats due to increases in
aging of the global population. Unfortunately, drugs for treating AD have been largely …
aging of the global population. Unfortunately, drugs for treating AD have been largely …
[HTML][HTML] V Diretriz da Sociedade Brasileira de Cardiologia sobre tratamento do infarto agudo do miocárdio com supradesnível do segmento ST
LS Piegas, A Timerman, GS Feitosa… - Arquivos brasileiros de …, 2015 - SciELO Brasil
Material de distribuição exclusiva à classe médica. Os Arquivos Brasileiros de Cardiologia
não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a …
não se responsabilizam pelo acesso indevido a seu conteúdo e que contrarie a …
Erectile dysfunction
R Shamloul, H Ghanem - The Lancet, 2013 - thelancet.com
Erectile dysfunction is a common clinical entity that affects mainly men older than 40 years.
In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and …
In addition to the classical causes of erectile dysfunction, such as diabetes mellitus and …
PDE5 inhibitors–pharmacology and clinical applications 20 years after sildenafil discovery
KE Andersson - British journal of pharmacology, 2018 - Wiley Online Library
The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …
normal physiological functions and the pathophysiology of several diseases. Since the …
[HTML][HTML] An overview of PDE4 inhibitors in clinical trials: 2010 to early 2022
L Crocetti, G Floresta, A Cilibrizzi, MP Giovannoni - Molecules, 2022 - mdpi.com
Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the
treatment of inflammation-based diseases. Several scientific advancements, by both …
treatment of inflammation-based diseases. Several scientific advancements, by both …