Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

The WD40 domain is one of the most abundant and interacting domains in the eukaryotic
genome. In proteins the WD domain folds into a β-propeller structure, providing a platform …

Smooth muscle cell migration has been implicated in the development of respiratory and
cardiovascular systems; and airway/vascular remodeling. Cell migration is a polarized …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

Cellular actin networks exhibit a wide range of sizes, shapes, and architectures tailored to
their biological roles. Once assembled, these filamentous networks are either maintained in …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

Various cellular processes (including cell motility) are driven by the regulated, polarized
assembly of actin filaments into distinct force-producing arrays of defined size and …

Activation of the Arp2/3 complex by VCA‐motif‐bearing actin nucleation‐promoting factors
results in the formation of “daughter” actin filaments branching off the sides of pre‐existing …

Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for
the regulation of actin reorganization in response to various signals. Accumulating evidence …