PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance
The Poly (ADP-ribose) polymerase (PARP) family has many essential functions in cellular
processes, including the regulation of transcription, apoptosis and the DNA damage …
processes, including the regulation of transcription, apoptosis and the DNA damage …
PARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directions
GE Konecny, RS Kristeleit - British journal of cancer, 2016 - nature.com
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors cause targeted tumour cell death
in homologous recombination (HR)-deficient cancers, including BRCA-mutated tumours, by …
in homologous recombination (HR)-deficient cancers, including BRCA-mutated tumours, by …
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
XRCC1 prevents toxic PARP1 trapping during DNA base excision repair
AA Demin, K Hirota, M Tsuda, M Adamowicz… - Molecular cell, 2021 - cell.com
Mammalian DNA base excision repair (BER) is accelerated by poly (ADP-ribose)
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect …
Eukaryotic base excision repair: new approaches shine light on mechanism
WA Beard, JK Horton, R Prasad… - Annual review of …, 2019 - annualreviews.org
Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
Immediate-early, early, and late responses to DNA double stranded breaks
SR Kieffer, NF Lowndes - Frontiers in Genetics, 2022 - frontiersin.org
Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …
Preclinical In Vivo Validation of the RAD51 Test for Identification of Homologous Recombination-Deficient Tumors and Patient Stratification
B Pellegrino, A Herencia-Ropero, A Llop-Guevara… - Cancer research, 2022 - AACR
PARP inhibitors (PARPi) are approved drugs for platinum-sensitive, high-grade serous
ovarian cancer (HGSOC) and for breast, prostate, and pancreatic cancers (PaC) harboring …
ovarian cancer (HGSOC) and for breast, prostate, and pancreatic cancers (PaC) harboring …
[HTML][HTML] DNA repair mechanisms and their clinical impact in glioblastoma
H Erasimus, M Gobin, S Niclou, E Van Dyck - Mutation Research/Reviews …, 2016 - Elsevier
Despite surgical resection and genotoxic treatment with ionizing radiation and the DNA
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …
alkylating agent temozolomide, glioblastoma remains one of the most lethal cancers, due in …
PARP inhibitors in ovarian cancer
G Mittica, E Ghisoni, G Giannone… - Recent patents on …, 2018 - ingentaconnect.com
Background: Treatment of Epithelial Ovarian Cancer (EOC), historically based on surgery
and platinum doublet chemotherapy, is associated with high risk of relapse and poor …
and platinum doublet chemotherapy, is associated with high risk of relapse and poor …
Exploiting synthetic lethality to target BRCA1/2-deficient tumors: where we stand
PS Patel, A Algouneh, R Hakem - Oncogene, 2021 - nature.com
The principle of synthetic lethality, which refers to the loss of viability resulting from the
disruption of two genes, which, individually, do not cause lethality, has become an attractive …
disruption of two genes, which, individually, do not cause lethality, has become an attractive …