100 years of Mycobacterium bovis bacille Calmette-Guérin

C Lange, P Aaby, MA Behr, PR Donald… - The Lancet Infectious …, 2022 - thelancet.com
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …

Therapeutic vaccines for tuberculosis: an overview

R Bouzeyen, B Javid - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world's deadliest bacterial
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …

Tuberculosis vaccine: A journey from BCG to present

S Fatima, A Kumari, G Das, VP Dwivedi - Life sciences, 2020 - Elsevier
Tuberculosis (TB) is the leading cause of death worldwide due to an infectious disease,
causing around 1.6 million deaths each year. This situation has become more complicated …

Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

[PDF][PDF] Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs

M Asai, Y Li, SM Newton, BD Robertson… - FEMS Microbiology …, 2023 - academic.oup.com
Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious
disease models, due to ease of use and the presence of an innate immune system …

The potential role of vaccines in preventing antimicrobial resistance (AMR): An update and future perspectives

V Costanzo, GN Roviello - Vaccines, 2023 - mdpi.com
In the modern era, the consumption of antibiotics represents a revolutionary weapon against
several infectious diseases, contributing to the saving of millions of lives worldwide …

Moving tuberculosis vaccines from theory to practice

P Andersen, TJ Scriba - Nature Reviews Immunology, 2019 - nature.com
Tuberculosis (TB) vaccine research has reached a unique point in time. Breakthrough
findings in both the basic immunology of Mycobacterium tuberculosis infection and the …

Controlled human infection models to accelerate vaccine development

RKM Choy, AL Bourgeois… - Clinical Microbiology …, 2022 - Am Soc Microbiol
The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Vaccine development against tuberculosis over the last 140 years: Failure as part of success

SHE Kaufmann - Frontiers in Microbiology, 2021 - frontiersin.org
The year 2020 was shaped by the COVID-19 pandemic which killed more people than any
other infectious disease in this particular year. At the same time, the development of highly …

The current status, challenges, and future developments of new tuberculosis vaccines

W Gong, Y Liang, X Wu - Human vaccines & immunotherapeutics, 2018 - Taylor & Francis
Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of
death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain …