Abstract Hypoxia-inducible factors (HIFs), a family of transcription factors activated by
hypoxia, consist of three α-subunits (HIF1α, HIF2α and HIF3α) and one β-subunit (HIF1β) …

Tumor hypoxia is a common feature in most solid tumors and is associated with
overexpression of the hypoxia response pathway. Overexpression of the hypoxia‐inducible …

Hypoxia is a significant feature of solid tumor cancers. Hypoxia leads to a more malignant
phenotype that is resistant to chemotherapy and radiation, is more invasive and has greater …

Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …

Uveal melanoma is the most common intraocular malignancy although it is a rare subset of
all melanomas. Uveal melanoma has distinct biology relative to cutaneous melanoma, with …

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and
patients that develop metastases (~ 50%) survive< 1 year, highlighting the urgent need for …

A new series of benzoxazine-6-sulfonamide derivatives were synthesized in excellent yields
and the resulting compounds were evaluated for their antimicrobial activities. All the …

Purpose: Uveal melanoma (UM) is the most prevalent and lethal intraocular malignancy in
adults. Here, we examined the importance of hypoxia in UM growth and tested the antitumor …

Purpose: The hypoxia-inducible factor-1 (HIF-1) plays a critical role in tumor adaptation to
hypoxia, and its elevated expression correlates with poor prognosis and treatment failure in …

In this work, new sulfonylhydrazone compounds with alkyl derivatives (SH1–SH4 series)
were synthesized via a green chemistry method, and their inhibition effects on …