Bioengineered nanogels for cancer immunotherapy

X Ma, SJ Li, Y Liu, T Zhang, P Xue, Y Kang… - Chemical Society …, 2022 - pubs.rsc.org
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …

[HTML][HTML] Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

C Saraiva, C Praça, R Ferreira, T Santos… - Journal of controlled …, 2016 - Elsevier
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …

Targeting the transferrin receptor for brain drug delivery

KB Johnsen, A Burkhart, LB Thomsen… - Progress in …, 2019 - Elsevier
Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Chitosan and chitosan coating nanoparticles for the treatment of brain disease

S Yu, X Xu, J Feng, M Liu, K Hu - International journal of pharmaceutics, 2019 - Elsevier
Since the application of chitosan magnetic cationic microspheres in brain drug delivery by
Gallo in 1993, chitosan has been extensively studied in brain drug delivery. As the only …

Challenges associated with penetration of nanoparticles across cell and tissue barriers: a review of current status and future prospects

S Barua, S Mitragotri - Nano today, 2014 - Elsevier
Nanoparticles (NPs) have emerged as an effective modality for the treatment of various
diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs …

Rethinking CRITID procedure of brain targeting drug delivery: circulation, blood brain barrier recognition, intracellular transport, diseased cell targeting, internalization …

S Ruan, Y Zhou, X Jiang, H Gao - Advanced Science, 2021 - Wiley Online Library
The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology

KE Sapsford, WR Algar, L Berti, KB Gemmill… - Chemical …, 2013 - ACS Publications
Bionanotechnology has now become firmly established in its own right as one of the
principle and focused subdisciplines within nanotechnology.(1-10) Bionanotechnology can …

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

J Nicolas, S Mura, D Brambilla, N Mackiewicz… - Chemical Society …, 2013 - pubs.rsc.org
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

N Kamaly, Z Xiao, PM Valencia… - Chemical Society …, 2012 - pubs.rsc.org
Polymeric materials have been used in a range of pharmaceutical and biotechnology
products for more than 40 years. These materials have evolved from their earlier use as …

Key for crossing the BBB with nanoparticles: The rational design

SM Lombardo, M Schneider, AE Türeli… - Beilstein journal of …, 2020 - beilstein-journals.org
Central nervous system diseases are a heavy burden on society and health care systems.
Hence, the delivery of drugs to the brain has gained more and more interest. The brain is …