Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants

AT Jan, M Azam, K Siddiqui, A Ali, I Choi… - International journal of …, 2015 - mdpi.com
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

Sulfhydryl groups as targets of mercury toxicity

OP Ajsuvakova, AA Tinkov, M Aschner… - Coordination chemistry …, 2020 - Elsevier
The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury

M Farina, DS Avila, JBT Da Rocha… - Neurochemistry …, 2013 - Elsevier
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …

[图书][B] Handbook on the Toxicology of Metals: Volume II: Specific Metals

GF Nordberg, M Costa - 2021 - books.google.com
Handbook on the Toxicology of Metals, Volume II: Specific Metals, Fifth Edition provides
complete coverage of 38 individual metals and their compounds. This volume is the second …

The toxicology of mercury and its compounds

T Syversen, P Kaur - Journal of Trace Elements in Medicine and Biology, 2012 - Elsevier
A concentrated review on the toxicology of inorganic mercury together with an extensive
review on the neurotoxicology of methylmercury is presented. The challenges of using …

Microbial mercury methylation in aquatic environments: a critical review of published field and laboratory studies

O Regnell, CJ Watras - Environmental science & technology, 2018 - ACS Publications
Methylmercury (MeHg) is an environmental contaminant of concern because it biomagnifies
in aquatic food webs and poses a health hazard to aquatic biota, piscivorous wildlife and …

Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies

M Farina, JBT Rocha, M Aschner - Life sciences, 2011 - Elsevier
Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …

Neurotoxicity linked to dysfunctional metal ion homeostasis and xenobiotic metal exposure: redox signaling and oxidative stress

C Garza-Lombó, Y Posadas, L Quintanar… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Iron brain menace: the involvement of ferroptosis in Parkinson disease

KJ Lin, SD Chen, KL Lin, CW Liou, MY Lan… - Cells, 2022 - mdpi.com
Parkinson disease (PD) is the second-most common neurodegenerative disease. The
characteristic pathology of progressive dopaminergic neuronal loss in people with PD is …