Neuronal cell-type classification: challenges, opportunities and the path forward

H Zeng, JR Sanes - Nature Reviews Neuroscience, 2017 - nature.com
Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity—and thereby pave the way for …

Disentangling neural cell diversity using single-cell transcriptomics

JF Poulin, B Tasic, J Hjerling-Leffler, JM Trimarchi… - Nature …, 2016 - nature.com
Cellular specialization is particularly prominent in mammalian nervous systems, which are
composed of millions to billions of neurons that appear in thousands of different'flavors' and …

[PDF][PDF] The Allen mouse brain common coordinate framework: a 3D reference atlas

Q Wang, SL Ding, Y Li, J Royall, D Feng, P Lesnar… - Cell, 2020 - cell.com
Recent large-scale collaborations are generating major surveys of cell types and
connections in the mouse brain, collecting large amounts of data across modalities, spatial …

[PDF][PDF] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells

NW Gouwens, SA Sorensen, F Baftizadeh, A Budzillo… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Hierarchical organization of cortical and thalamic connectivity

JA Harris, S Mihalas, KE Hirokawa, JD Whitesell… - Nature, 2019 - nature.com
The mammalian cortex is a laminar structure containing many areas and cell types that are
densely interconnected in complex ways, and for which generalizable principles of …

[HTML][HTML] Shared and distinct transcriptomic cell types across neocortical areas

B Tasic, Z Yao, LT Graybuck, KA Smith, TN Nguyen… - Nature, 2018 - nature.com
The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

Mouse retinal cell atlas: molecular identification of over sixty amacrine cell types

W Yan, MA Laboulaye, NM Tran… - Journal of …, 2020 - Soc Neuroscience
Amacrine cells (ACs) are a diverse class of interneurons that modulate input from
photoreceptors to retinal ganglion cells (RGCs), rendering each RGC type selectively …

[PDF][PDF] A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality

TL Daigle, L Madisen, TA Hage, MT Valley, U Knoblich… - Cell, 2018 - cell.com
Modern genetic approaches are powerful in providing access to diverse cell types in the
brain and facilitating the study of their function. Here, we report a large set of driver and …

Genetic dissection of the glutamatergic neuron system in cerebral cortex

KS Matho, D Huilgol, W Galbavy, M He, G Kim, X An… - Nature, 2021 - nature.com
Diverse types of glutamatergic pyramidal neurons mediate the myriad processing streams
and output channels of the cerebral cortex,, yet all derive from neural progenitors of the …

[HTML][HTML] Cellular anatomy of the mouse primary motor cortex

R Muñoz-Castañeda, B Zingg, KS Matho, X Chen… - Nature, 2021 - nature.com
An essential step toward understanding brain function is to establish a structural framework
with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and …