Diabetes mellitus is a metabolic disorder that affects more than 460 million people
worldwide. Type 1 diabetes (T1D) is caused by autoimmune destruction of β-cells, whereas …

The Adhesion family forms a large branch of the pharmacologically important superfamily of
G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention …

Transplantation of pancreatic progenitors or insulin-secreting cells derived from human
embryonic stem cells (hESCs) has been proposed as a therapy for diabetes. We describe a …

Deciphering mechanisms of endocrine cell induction, specification and lineage allocation in
vivo will provide valuable insights into how the islets of Langerhans are generated …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Adhesion-type heterotrimeric guanine nucleotide–binding protein (G protein)–coupled
receptors (Adhesion-GPCRs) comprise a class of widely distributed seven-transmembrane …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

The genomic regulatory programmes that underlie human organogenesis are poorly
understood. Pancreas development, in particular, has pivotal implications for pancreatic …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

Generating an unlimited source of human insulin-producing cells is a prerequisite to
advance β cell replacement therapy for diabetes. Here, we describe a 3D culture system that …