Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Plant-parasitic nematodes have caused huge economic losses to agriculture worldwide and
seriously threaten the sustainable development of modern agriculture. Chemical …

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing
histone deacetylation. Aberrant expression of HDACs is associated with various human …

Introduction: Histone deacetylase (HDAC) inhibitors play a crucial role in restoring the
balance of acetylation and deacetylation of lysine residues of histones and non-histone …

This review classifies drug‐design strategies successfully implemented in the development
of histone deacetylase (HDAC) inhibitors, which have many applications including cancer …

In this study, we report the first highly selective HDAC6 inhibitor with hydrazide as the zinc-
binding group (ZBG), which displays superior pharmacokinetic properties to the current …

Histone deacetylases (HDACs) are clinically validated epigenetic drug targets for cancer
treatment. HDACs inhibitors (HDACis) have been successfully applied against a series of …

Histone deacetylase HDAC6, a member of the class IIb HDAC family, is unique among
HDAC enzymes in having two active catalytic domains, and has unique physiological …

We have developed a photoinduced protocol for the synthesis of pharmaceutically important
oxazole molecules using diazo‐and nitrile‐containing reactants. The process involves the …