Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

To metabolomics and beyond: a technological portfolio to investigate cancer metabolism

F Danzi, R Pacchiana, A Mafficini, MT Scupoli… - … and Targeted Therapy, 2023 - nature.com
Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis

G Wang, M Qiu, X Xing, J Zhou, H Yao, M Li… - Science Translational …, 2022 - science.org
Lung cancer is the leading cause of cancer mortality, and early detection is key to improving
survival. However, there are no reliable blood-based tests currently available for early-stage …

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

M Sud, E Fahy, D Cotter, K Azam, I Vadivelu… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Metabolomics Workbench, available at www. metabolomicsworkbench. org, is
a public repository for metabolomics metadata and experimental data spanning various …

Atlas of circadian metabolism reveals system-wide coordination and communication between clocks

KA Dyar, D Lutter, A Artati, NJ Ceglia, Y Liu, D Armenta… - Cell, 2018 - cell.com
Metabolic diseases are often characterized by circadian misalignment in different tissues,
yet how altered coordination and communication among tissue clocks relate to specific …

Quality assurance procedures for mass spectrometry untargeted metabolomics. a review

D Dudzik, C Barbas-Bernardos, A García… - … of pharmaceutical and …, 2018 - Elsevier
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Single-cell metabolomics: analytical and biological perspectives

R Zenobi - Science, 2013 - science.org
Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …

MetaboLights—an open-access general-purpose repository for metabolomics studies and associated meta-data

K Haug, RM Salek, P Conesa, J Hastings… - Nucleic acids …, 2013 - academic.oup.com
Abstract MetaboLights (http://www. ebi. ac. uk/metabolights) is the first general-purpose,
open-access repository for metabolomics studies, their raw experimental data and …

Systems biology primer: the basic methods and approaches

I Tavassoly, J Goldfarb, R Iyengar - Essays in biochemistry, 2018 - portlandpress.com
Systems biology is an integrative discipline connecting the molecular components within a
single biological scale and also among different scales (eg cells, tissues and organ systems) …

HMDB: the human metabolome database

DS Wishart, D Tzur, C Knox, R Eisner… - Nucleic acids …, 2007 - academic.oup.com
Abstract The Human Metabolome Database (HMDB) is currently the most complete and
comprehensive curated collection of human metabolite and human metabolism data in the …