This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

There is a growing consensus that the various forms of cell death (necrosis, apoptosis and
autophagy) are not separated by strict boundaries, but rather share molecular effectors and …

In electrically nonexcitable cells, Ca2+ influx is essential for regulating a host of kinetically
distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and …

The past few years have witnessed dramatic progress on all frontiers of zinc neurobiology.
The recent development of powerful tools, including zinc-sensitive fluorescent probes …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

Our understanding of the underlying mechanisms of Ca2+ signaling as well as our
appreciation for its ubiquitous role in cellular processes has been rapidly advanced, in large …

Elevation of intracellular free Ca2+ is one of the key triggering signals for T-cell activation by
antigen. A remarkable variety of Ca2+ signals in T cells, ranging from infrequent spikes to …

Impaired homeostasis of lysosomal Ca2+ causes lysosome dysfunction and lysosomal
storage diseases (LSDs), but the mechanisms by which lysosomes acquire and refill Ca2+ …

Modulation of many signaling pathways in antigen-stimulated T and B cells results in global
changes in gene expression. Here we investigate the contribution of calcium signaling to …