As one of the deadliest diseases, cancer frequently resists existing therapeutics because
they do not target all cells within a progressing tumor, for example both tumor stem and …

Heat-shock-protein family A (Hsp70) member 5 (HSPA5), aliases GRP78 or BiP, is a protein
encoded with 654 amino acids by the HSPA5 gene located on human chromosome 9q33. 3 …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

Abstract HSPA5 (BiP, GRP78) has been reported as a potential host-cell receptor for SARS-
Cov-2, but its expression profiles on different tissues including tumors, its susceptibility to …

The protein chaperone GRP78 is a master regulator of endoplasmic reticulum (ER) functions
and is frequently over-expressed at the surface of cancer cells where it contributes to chemo …

Cell surface GRP78 (csGRP78, glucose-regulated protein 78 kDa) is preferentially
overexpressed in aggressive, metastatic, and chemo-resistant cancers. GRP78 is best …

Fluorescent cyclic peptides are excellent chemical scaffolds to build optical agents for
molecular imaging. In addition to their favorable physicochemical properties, they can be …

Abstract Isthmin 1 (Ism1) has been shown to play roles in multiple biological processes
including morphogenesis, hematopoiesis, antiviral immune response and suppression of …

The 78 kDa glucose-regulated protein (GRP78), a member of the 70 kDa heat-shock family
of molecular chaperones (HSP70), is essential for the regulation of the unfolded protein …

Cardiovascular disease is the leading cause of death worldwide. Despite overwhelming
socioeconomic impact and mounting clinical needs, our understanding of the underlying …