Obesity is a major health problem strongly increasing the risk for various severe related
complications such as metabolic syndrome, cardiovascular diseases, respiratory disorders …

Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Non-alcoholic fatty liver disease (NAFLD) is recognized as the most common type of chronic
liver disease in Western countries. Insulin resistance is a key factor in the pathogenesis of …

The utility of human pluripotent stem cells is dependent on efficient differentiation protocols
that convert these cells into relevant adult cell types. Here we report the robust and efficient …

Adiponectin is an adipokine first described just over a decade ago. Produced almost
exclusively by adipocytes, adiponectin circulates in high concentrations in human plasma …

Adipose tissue is a key regulator of energy balance playing an active role in lipid storage as
well as in synthesizing several hormones directly involved in the pathogenesis of obesity …

Adiponectin regulates metabolism through blood glucose control and fatty acid oxidation,
partly mediated by downstream effects of adiponectin signaling in skeletal muscle. More …

Thiazolidinediones (TZDs; pioglitazone and rosiglitazone) have provided promising results
in clinical trials for nonalcoholic steatohepatitis (NASH). The main purpose of this systematic …

The adipose tissue is not only an inert storage depot for lipids, but also it secretes a variety
of bioactive molecules, known as adipokines, which affect whole-body homeostasis …

Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an
overall survival of 5% at five years. The development of PDAC is characteristically …