The role of peroxisome proliferator-activated receptors (PPAR) in immune responses
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors
S Francque, G Szabo, MF Abdelmalek… - Nature reviews …, 2021 - nature.com
The increasing epidemic of obesity worldwide is linked to serious health effects, including
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …
increased prevalence of type 2 diabetes mellitus, cardiovascular disease and nonalcoholic …
PPAR agonists and metabolic syndrome: an established role?
M Botta, M Audano, A Sahebkar, CR Sirtori… - International journal of …, 2018 - mdpi.com
Therapeutic approaches to metabolic syndrome (MetS) are numerous and may target
lipoproteins, blood pressure or anthropometric indices. Peroxisome proliferator-activated …
lipoproteins, blood pressure or anthropometric indices. Peroxisome proliferator-activated …
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk
Blood lipid levels are heritable, treatable risk factors for cardiovascular disease. We
systematically assessed genome-wide coding variation to identify new genes influencing …
systematically assessed genome-wide coding variation to identify new genes influencing …
Control of macrophage activation and function by PPARs
A Chawla - Circulation research, 2010 - Am Heart Assoc
Macrophages, a key component of the innate defense against pathogens, participate in the
initiation and resolution of inflammation, and in the maintenance of tissues. These diverse …
initiation and resolution of inflammation, and in the maintenance of tissues. These diverse …
PPAR beta/delta and the hallmarks of cancer
N Wagner, KD Wagner - Cells, 2020 - mdpi.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone
receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma …
receptor family. Three different isoforms, PPAR alpha, PPAR beta/delta and PPAR gamma …
Physiological functions of peroxisome proliferator-activated receptor β
JG Neels, PA Grimaldi - Physiological reviews, 2014 - journals.physiology.org
The peroxisome proliferator-activated receptors, PPARα, PPARβ, and PPARγ, are a family of
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …
transcription factors activated by a diversity of molecules including fatty acids and fatty acid …
Peroxisome proliferator-activated receptor δ regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury
KJ Yin, Z Deng, M Hamblin, Y Xiang… - Journal of …, 2010 - Soc Neuroscience
Cerebral vascular endothelial cell (CEC) degeneration significantly contributes to blood–
brain barrier (BBB) breakdown and neuronal loss after cerebral ischemia. Recently …
brain barrier (BBB) breakdown and neuronal loss after cerebral ischemia. Recently …
PPARs and the cardiovascular system
M Hamblin, L Chang, Y Fan, J Zhang… - Antioxidants & redox …, 2009 - liebertpub.com
Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear hormone-
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …
receptor superfamily. Originally cloned in 1990, PPARs were found to be mediators of …
TFEB inhibits endothelial cell inflammation and reduces atherosclerosis
Transcription factor EB (TFEB) is a master regulator of autophagy and lysosome biogenesis.
We investigated the function of TFEB in vascular biology and pathophysiology and …
We investigated the function of TFEB in vascular biology and pathophysiology and …