Autophagy as an emerging target in cardiorenal metabolic disease: from pathophysiology to management
Y Zhang, AT Whaley-Connell, JR Sowers… - Pharmacology & …, 2018 - Elsevier
Although advances in medical technology and health care have improved the early
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …
diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity …
Dual roles of the AMP-activated protein kinase pathway in angiogenesis
Angiogenesis plays important roles in development, stress response, wound healing,
tumorigenesis and cancer progression, diabetic retinopathy, and age-related macular …
tumorigenesis and cancer progression, diabetic retinopathy, and age-related macular …
[HTML][HTML] Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through …
C Li, L Lin, L Zhang, R Xu, X Chen, J Ji, Y Li - Pharmacological Research, 2021 - Elsevier
Vascular damage of hypertension has been the focus of hypertension treatment, and
endothelial progenitor cells (EPCs) play an important role in the repair of vascular …
endothelial progenitor cells (EPCs) play an important role in the repair of vascular …
Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p …
R Shi, Y Jin, W Hu, W Lian, C Cao… - … of Physiology-Cell …, 2020 - journals.physiology.org
More and more evidence advises that circular RNAs (circRNAs) function critically in
regulating different disease microenvironments. Our previous study found that …
regulating different disease microenvironments. Our previous study found that …
Procyanidin B2 improves endothelial progenitor cell function and promotes wound healing in diabetic mice via activating Nrf2
J Fan, H Liu, J Wang, J Zeng, Y Tan… - Journal of Cellular …, 2021 - Wiley Online Library
One of the major reasons for the delayed wound healing in diabetes is the dysfunction of
endothelial progenitor cells (EPCs) induced by hyperglycaemia. Improvement of EPC …
endothelial progenitor cells (EPCs) induced by hyperglycaemia. Improvement of EPC …
Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells
Autophagy plays a critical role in the dynamic growth of each cell through different
conditions. It seems that this intracellular mechanism acts as a two-edged sword against the …
conditions. It seems that this intracellular mechanism acts as a two-edged sword against the …
Effects of newly introduced antidiabetic drugs on autophagy
Diabetes mellitus is a chronic metabolic disorder that has a complex molecular and cellular
pathophysiology, resulting in its dynamic progression and that may show differing responses …
pathophysiology, resulting in its dynamic progression and that may show differing responses …
Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways
L Varisli, O Cen, S Vlahopoulos - Immunology, 2020 - Wiley Online Library
Chloroquines are 4‐aminoquinoline‐based drugs mainly used to treat malaria. At
pharmacological concentrations, they have significant effects on tissue homeostasis …
pharmacological concentrations, they have significant effects on tissue homeostasis …
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway
X Wang, X Che, Y Yu, Y Cheng, M Bai, Z Yang… - Journal of Experimental …, 2020 - Springer
Background Peritoneal metastasis (PM) is an important pathological process in the
progression of gastric cancer (GC). The metastatic potential of tumor and stromal cells is …
progression of gastric cancer (GC). The metastatic potential of tumor and stromal cells is …
Endothelial overexpression of metallothionein prevents diabetes-induced impairment in ischemia angiogenesis through preservation of HIF-1α/SDF-1/VEGF signaling …
Diabetes-induced oxidative stress is one of the major contributors to dysfunction of
endothelial progenitor cells (EPCs) and impaired endothelial regeneration. Thus, we tested …
endothelial progenitor cells (EPCs) and impaired endothelial regeneration. Thus, we tested …