Over the last quarter-century, there has been tremendous progress in genetics research that
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …

Hypertrophic cardiomyopathy is a common genetically transmitted disease, defined clinically
by the presence of unexplained left ventricular hypertrophy. The disease has a varied …

Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular
disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting …

Cardiomyopathies (ie, diseases of the heart muscle) are major causes of morbidity and
mortality. A significant percentage of patients with cardiomyopathies have genetic-based …

Hypertrophic cardiomyopathy (HCM) is a common inherited cardiac disorder that
characterized by marked thickening of the left ventricular wall that occurs in the absence of …

Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous cardiac muscle
disorder with a diverse natural history, characterized by unexplained left ventricular …

Hypertrophic cardiomyopathy (HCM) is the most-common monogenically inherited form of
heart disease, characterized by thickening of the left ventricular wall, contractile dysfunction …

Inherited cardiomyopathies include hypertrophic cardiomyopathy, dilated cardiomyopathy,
arrhythmogenic right ventricular cardiomyopathy, left ventricular noncompaction, and …

Cardiac hypertrophy is a major risk factor for heart failure, and it has been shown that this
increase in size occurs at the level of the cardiac myocyte. Cardiac myocyte model systems …

Dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality. Two genes have
been identified for the X-linked forms (dystrophin and tafazzin), while mutations in multiple …