Discovery of novel amide derivatives against VEGFR-2/tubulin with potent antitumor and antiangiogenic activity
Z Liu, S Mao, H Li, W Liu, J Tao, Y Lu, H Dong… - Bioorganic …, 2024 - Elsevier
Dual-target agents have more advantages than drug combinations for cancer treatment.
Here, we designed and synthesized a series of novel VEGFR-2/tubulin dual-target inhibitors …
Here, we designed and synthesized a series of novel VEGFR-2/tubulin dual-target inhibitors …
Heterogeneous distribution of kinesin-streptavidin complexes revealed by Mass Photometry
Kinesin-streptavidin complexes are widely used in microtubule-based active-matter studies.
The stoichiometry of the complexes is empirically tuned but experimentally challenging to …
The stoichiometry of the complexes is empirically tuned but experimentally challenging to …
Contractile to extensile transitions and mechanical adaptability enabled by activity in cytoskeletal structures
In this study, we investigate the response of self-assembled cytoskeletal structures to
external mechanical perturbations, focusing on filament and crosslinker mixtures in two …
external mechanical perturbations, focusing on filament and crosslinker mixtures in two …