Rab family of small GTPases: an updated view on their regulation and functions

Y Homma, S Hiragi, M Fukuda - The FEBS journal, 2021 - Wiley Online Library
The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

Image co-localization–co-occurrence versus correlation

JS Aaron, AB Taylor, TL Chew - Journal of cell science, 2018 - journals.biologists.com
Fluorescence image co-localization analysis is widely utilized to suggest biomolecular
interaction. However, there exists some confusion as to its correct implementation and …

Diverse long RNAs are differentially sorted into extracellular vesicles secreted by colorectal cancer cells

SA Hinger, DJ Cha, JL Franklin, JN Higginbotham… - Cell reports, 2018 - cell.com
The regulation and functional roles of secreted coding and long noncoding RNAs
(lncRNAs;> 200 nt) are largely unknown. We previously showed that mutant KRAS …

Rab-mediated vesicle trafficking in cancer

HT Tzeng, YC Wang - Journal of biomedical science, 2016 - Springer
A large group of small Rab GTPases which mediate secretory and endosomal membrane
transport, as well as autophagosome biogenesis, are essential components of vesicle …

Macropinosome formation by tent pole ruffling in macrophages

ND Condon, JM Heddleston, TL Chew, L Luo… - Journal of Cell …, 2018 - rupress.org
Pathogen-mediated activation of macrophages arms innate immune responses that include
enhanced surface ruffling and macropinocytosis for environmental sampling and receptor …

Dance of the Golgi: understanding Golgi dynamics in cancer metastasis

R Bajaj, AN Warner, JF Fradette, DL Gibbons - Cells, 2022 - mdpi.com
The Golgi apparatus is at the center of protein processing and trafficking in normal cells.
Under pathological conditions, such as in cancer, aberrant Golgi dynamics alter the tumor …

Epstein-Barr virus subverts mevalonate and fatty acid pathways to promote infected B-cell proliferation and survival

LW Wang, Z Wang, I Ersing, L Nobre, R Guo… - PLoS …, 2019 - journals.plos.org
Epstein-Barr virus (EBV) causes infectious mononucleosis and is associated with multiple
human malignancies. EBV drives B-cell proliferation, which contributes to the pathogenesis …

Regulation and outcomes of localized RNA translation

AN Gasparski, DE Mason… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Spatial segregation of mRNAs in the cytoplasm of cells is a well‐known biological
phenomenon that is widely observed in diverse species spanning different kingdoms of life …

Collective cancer cell invasion requires RNA accumulation at the invasive front

G Chrisafis, T Wang, K Moissoglu… - Proceedings of the …, 2020 - National Acad Sciences
Localization of RNAs at protrusive regions of cells is important for single-cell migration on
two-dimensional surfaces. Protrusion-enriched RNAs encode factors linked to cancer …

RNA localization and co‐translational interactions control RAB 13 GTP ase function and cell migration

K Moissoglu, M Stueland, AN Gasparski, T Wang… - The EMBO …, 2020 - embopress.org
Numerous RNA s exhibit specific distribution patterns in mammalian cells. However, the
functional and mechanistic consequences are relatively unknown. Here, we investigate the …