Tumor-induced osteomalacia (TIO) is an ultrarare paraneoplastic syndrome due to
overproduction of fibroblast growth factor 23 (FGF23), with profound effects on patient …

Osteocytes, which represent up to 95% of adult skeletal cells, are deeply embedded in bone.
These cells exhibit important interactive abilities with other bone cells such as osteoblasts …

Inflammation leads to functional iron deficiency by increasing the expression of the hepatic
iron regulatory peptide hepcidin. Inflammation also stimulates fibroblast growth factor 23 …

The seminal discoveries that parathyroid hormone (PTH) and fibroblast growth factor 23
(FGF23) are major endocrine regulators of vitamin D metabolism led to a significant …

Apart from its phosphaturic action, the bone derived hormone fibroblast growth factor 23
(FGF23) is also an essential regulator of vitamin D metabolism. The main target organ of …

The actions of several bone-mineral ion regulators, namely PTH, FGF23, Klotho and 1, 25
(OH) 2 vitamin D (1, 25 (OH) 2D), control calcium and phosphate metabolism, and each of …

The hormonal vitamin D metabolite, 1, 25‐dihydroxyvitamin D [1, 25 (OH) 2D], produced in
kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger …

Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious complication of
systemic lupus erythematosus (SLE) involving the nervous system with high morbidity and …

Mineral homeostasis of calcium and phosphate levels is one critical component to the
maintenance of bone mineral density (BMD) and strength. Diseases that disrupt calcium and …

The regulation of mineral homeostasis involves the three mineralotropic hormones PTH,
FGF23 and 1, 25-dihydroxyvitamin D3 (1, 25 (OH) 2D3). Early research efforts focused on …