Linezolid is an antibiotic used to treat infections caused by drug-resistant gram-positive
organisms, including vancomycin-resistant Enterococcus faecium, multi-drug resistant …

Over 480 000 cases of multidrug-resistant (MDR) tuberculosis (TB) occur every year
globally, 9% of them being affected by extensively drug-resistant (XDR) strains of …

Background: The American Thoracic Society, US Centers for Disease Control and
Prevention, European Respiratory Society, and Infectious Diseases Society of America …

Despite concerted efforts over the past 2 decades at developing new diagnostics, drugs, and
vaccines with expanding pipelines, tuberculosis remains a global emergency. Several novel …

Linezolid has been successfully used for treatment of multidrug-resistant tuberculosis (MDR-
TB). However, dose-and duration-related toxicity limit its use. Here, our aim was to search …

The oxazolidinone antibacterial linezolid has been in clinical use for over 20 years, yet
knowledge of the contributions of specific cytochrome (CYP) 450 enzymes to the metabolic …

Introduction Therapeutic drug monitoring (TDM) has been recommended for treatment
optimization in tuberculosis (TB) but is only is used in certain countries eg USA, Germany …

Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and
individualized treatment have been challenged since its approval. With the in-depth clinical …

Introduction: Linezolid is an oxazolidinone with potent activity against M tuberculosis, and
improves culture conversion and cure rates when added to treatment regimens for drug …

Introduction: Oxazolidinones are synthetic antimicrobials with strong bacteriostatic activity
against Gram-positive organisms. Recently, tedizolid phosphate was approved for clinical …