Chronic stress and brain plasticity: mechanisms underlying adaptive and maladaptive changes and implications for stress-related CNS disorders

J Radley, D Morilak, V Viau, S Campeau - Neuroscience & Biobehavioral …, 2015 - Elsevier
Stress responses entail neuroendocrine, autonomic, and behavioral changes to promote
effective coping with real or perceived threats to one's safety. While these responses are …

Sex differences in stress responses: focus on ovarian hormones

GJ Ter Horst, R Wichmann, M Gerrits… - Physiology & …, 2009 - Elsevier
Women in the reproductive age are more vulnerable to develop affective disorders than
men. This difference may attribute to anatomical differences, hormonal influences and …

Chronic high corticosterone reduces neurogenesis in the dentate gyrus of adult male and female rats

S Brummelte, LAM Galea - Neuroscience, 2010 - Elsevier
Adult neurogenesis in the dentate gyrus of the hippocampus is altered with stress exposure
and has been implicated in depression. High levels of corticosterone (CORT) suppress …

The lonely mouse: verification of a separation-induced model of depression in female mice

AL Martin, RE Brown - Behavioural brain research, 2010 - Elsevier
Animal models of depression seldom test females, even though women are twice as likely
as men to suffer from major depressive disorder. Since female mice are sensitive to social …

The role of the hypothalamus-pituitary-adrenal/interrenal axis in mediating predator-avoidance trade-offs

BN Harris, JA Carr - General and comparative endocrinology, 2016 - Elsevier
Maintaining energy balance and reproducing are important for fitness, yet animals have
evolved mechanisms by which the hypothalamus-pituitary-adrenal/interrenal (HPA/HPI) axis …

A novel chronic social stress paradigm in female mice

MV Schmidt, SH Scharf, C Liebl, D Harbich… - Hormones and …, 2010 - Elsevier
Major depression is one of the most prevalent stress-related psychiatric diseases. Next to
environmental influences such as chronic social stress, gender is among the strongest risk …

Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner

J Bakos, N Hlavacova, M Rajman, K Ondicova, C Koros… - Neuroscience, 2009 - Elsevier
The present study is aimed at testing the hypothesis that an enriched environment (EE)
induces sex-dependent changes in stress hormone release and in markers of increased …

Sex differences in risk-taking and associative learning in rats

JW Jolles, NJ Boogert… - Royal Society Open …, 2015 - royalsocietypublishing.org
In many species, males tend to have lower parental investment than females and greater
variance in their reproductive success. Males might therefore be expected to adopt more …

Tryptophan metabolism as a 'reflex'feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway

TW Stone, RO Williams - Journal of Neurochemistry, 2023 - Wiley Online Library
Although the central nervous system (CNS) and immune system were regarded as
independent entities, it is now clear that immune system cells can influence the CNS, and …

Predation threat exerts specific effects on rat maternal behaviour and anxiety-related behaviour of male and female offspring

R Mashoodh, CJ Sinal, TS Perrot-Sinal - Physiology & behavior, 2009 - Elsevier
Differences in the rate of maternal behaviours received by rodent offspring are associated
with differential programming of molecular and behavioural components of anxiety and …