[HTML][HTML] QA makes a clinical trial stronger: evidence-based medicine in radiation therapy

DC Weber, M Tomsej, C Melidis… - Radiotherapy and …, 2012 - Elsevier
Quality assurance (QA) for radiation therapy (RT) in clinical trials is necessary to ensure
treatment is safely and effectively administered. QA assurance requires however substantial …

A review of methods of analysis in contouring studies for radiation oncology

MG Jameson, LC Holloway, PJ Vial… - Journal of medical …, 2010 - Wiley Online Library
Inter‐observer variability in anatomical contouring is the biggest contributor to uncertainty in
radiation treatment planning. Contouring studies are frequently performed to investigate the …

Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with …

JW Denham, D Joseph, DS Lamb, NA Spry… - The lancet …, 2019 - thelancet.com
Background The optimal duration of androgen suppression for men with locally advanced
prostate cancer receiving radiotherapy with curative intent is yet to be defined. Zoledronic …

A national repository of complete radiotherapy plans: design, Results, and experiences

SL Krogh, C Brink, EL Lorenzen, E Samsøe… - Acta …, 2023 - Taylor & Francis
Background Previously, many radiotherapy (RT) trials were based on a few selected dose
measures. Many research questions, however, rely on access to the complete dose …

Radiation dose escalation or longer androgen suppression to prevent distant progression in men with locally advanced prostate cancer: 10-year data from the TROG …

D Joseph, JW Denham, A Steigler, DS Lamb… - International Journal of …, 2020 - Elsevier
Purpose To clarify the relative effects of duration of androgen suppression (AS) and
radiation dose escalation (RDE) on distant progression (DP) in men with locally advanced …

Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with …

JW Denham, D Joseph, DS Lamb, NA Spry… - The Lancet …, 2014 - thelancet.com
Background We investigated whether 18 months of androgen suppression plus
radiotherapy, with or without 18 months of zoledronic acid, is more effective than 6 months of …

Plan quality in radiotherapy treatment planning–Review of the factors and challenges

CR Hansen, M Hussein, U Bernchou… - Journal of Medical …, 2022 - Wiley Online Library
A high‐quality treatment plan aims to best achieve the clinical prescription, balancing high
target dose to maximise tumour control against sufficiently low organ‐at‐risk dose for …

Quality assurance for prospective EORTC radiation oncology trials: the challenges of advanced technology in a multicenter international setting

DC Weber, PMP Poortmans, CW Hurkmans… - Radiotherapy and …, 2011 - Elsevier
The European Organization for the Research and Treatment of Cancer (EORTC) is a pan-
European structure charged with improving cancer treatment through the testing of new …

Effect of androgen deprivation therapy on muscle attenuation in men with prostate cancer

D Chang, DJ Joseph, MA Ebert… - Journal of medical …, 2014 - Wiley Online Library
Introduction Aging skeletal muscle is associated with not only a reduction in muscle size and
strength but also in muscle quality which reflects an increase in fatty infiltration of muscle. In …

Modeling urinary dysfunction after external beam radiation therapy of the prostate using bladder dose-surface maps: evidence of spatially variable response of the …

N Yahya, MA Ebert, MJ House, A Kennedy… - International Journal of …, 2017 - Elsevier
Purpose We assessed the association of the spatial distribution of dose to the bladder
surface, described using dose-surface maps, with the risk of urinary dysfunction. Methods …