Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease
(NAFLD), is a common hepatic condition that encompasses a wide spectrum of …

Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

The worldwide obesity epidemic has become a major health concern, because it contributes
to higher mortality due to an increased risk for noncommunicable diseases including …

Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However,
the mechanism by which this occurs has not yet been uncovered. Here, we investigated the …

As a key regulator of cellular calcium homeostasis, the Sarcoendoplasmic Reticulum
Calcium ATPase (SERCA) pump acts to transport calcium ions from the cytosol back to the …

Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …

Impaired insulin secretion is a hallmark in type 2 diabetes mellitus (T2DM). THADA has
been identified as a candidate gene for T2DM, but its role in glucose homeostasis remains …

Wolfram syndrome is a rare genetic disease caused by mutations in the WFS1 or CISD2
gene. A primary defect in Wolfram syndrome involves poor ER Ca2+ handling, but how this …

The execution of proper Ca 2+ signaling requires close apposition between the
endoplasmic reticulum (ER) and mitochondria. Hence, Ca 2+ released from the ER is “quasi …