Piroxicam (PXM), a nonsteroidal anti-inflammatory drug, is an enolic benzothiazine and a
potent member of the oxicam series. The drug suppresses the synthesis of proinflammatory …

Background: Wound healing is a complex process including hemostasis, inflammation,
proliferation, and remodeling during which an orchestrated array of biological and molecular …

Balancing skin hydration levels is important as any disruption in skin integrity will result in
disturbance of the dermal water balance. The discovery that a moist environment actively …

Even though elderly populations lack visible or other clinical signs of inflammation, their
serum cytokine and C-reactive protein levels typically are elevated. However, the origin of …

Background The pathogenesis underlying keloid formation is still poorly understood.
Research has focused mostly on dermal abnormalities, while the epidermis has not yet been …

Topical administration permits targeted, sustained delivery of therapeutics to human skin.
Delivery to the skin, however, is typically limited to lipophilic molecules with molecular …

The most critical function of the epidermis is to prevent water loss and maintain skin
homeostasis. Disruption of the functional skin barrier causes delayed wound healing …

The mechanisms by which the epidermis responds to disturbances in barrier function and
restores homeostasis are unknown. With a perturbation of the epidermal barrier, water is …

As we are aging, a number of cutaneous and extracutaneous disorders will be developed.
Although the pathogenesis of these aging-associated disorders is not clear yet …

Damage to epidermis results in loss of barrier function and resultant pathological
inflammatory signaling, triggering further damage to the skin. Here we investigate …