T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
[HTML][HTML] SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition
T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …
but also for the development of vaccines, identification of exact viral T cell epitopes is …
[HTML][HTML] Deconstructing the peptide-MHC specificity of T cell recognition
In order to survey a universe of major histocompatibility complex (MHC)-presented peptide
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …
antigens whose numbers greatly exceed the diversity of the T cell repertoire, T cell receptors …
Non-mutational neoantigens in disease
The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …
establishment of immunological memory is predicated on the ability of the mature T cell …
Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination
Y Maringer, A Nelde, SM Schroeder… - Science …, 2022 - science.org
Several COVID-19 vaccines are approved to prevent severe disease outcome after SARS-
CoV-2 infection. Whereas induction and functionality of antiviral antibody response are …
CoV-2 infection. Whereas induction and functionality of antiviral antibody response are …
Why must T cells be cross-reactive?
AK Sewell - Nature Reviews Immunology, 2012 - nature.com
Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
The discriminatory power of the T cell receptor
J Pettmann, A Huhn, E Abu Shah, MA Kutuzov… - Elife, 2021 - elifesciences.org
T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) …
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) …
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning
Computational modelling of the interactions between T-cell receptors (TCRs) and epitopes
is of great importance for immunotherapy and antigen discovery. However, current TCR …
is of great importance for immunotherapy and antigen discovery. However, current TCR …