New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

Progress and perspectives on directing group-assisted palladium-catalysed C–H functionalisation of amino acids and peptides

S Shabani, Y Wu, HG Ryan, CA Hutton - Chemical Society Reviews, 2021 - pubs.rsc.org
Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …

Discovery and biosynthesis of cyclic plant peptides via autocatalytic cyclases

DN Chigumba, LS Mydy, F de Waal, W Li… - Nature Chemical …, 2022 - nature.com
Many bioactive plant cyclic peptides form side-chain-derived macrocycles. Lyciumins, cyclic
plant peptides with tryptophan macrocyclizations, are ribosomal peptides (RiPPs) originating …

The biosynthetic landscape of triceptides reveals radical SAM enzymes that catalyze cyclophane formation on Tyr-and His-containing motifs

R Sugiyama, AFL Suarez, Y Morishita… - Journal of the …, 2022 - ACS Publications
Peptide-derived cyclophanes inhabit a unique niche in the chemical space of macrocyclic
peptides with several examples of pharmaceutical importance. Although both synthetic and …

Post-translational formation of strained cyclophanes in bacteria

TQN Nguyen, YW Tooh, R Sugiyama, TPD Nguyen… - Nature Chemistry, 2020 - nature.com
Cyclic peptide natural products have served as important drug molecules, with several
examples used clinically. Enzymatic or chemical macrocyclization is the key transformation …

Discovery and biosynthesis of tricyclic copper-binding ribosomal peptides containing histidine-to-butyrine crosslinks

Y Li, Y Ma, Y Xia, T Zhang, S Sun, J Gao, H Yao… - Nature …, 2023 - nature.com
Cyclic peptide natural products represent an important class of bioactive compounds and
clinical drugs. Enzymatic side-chain macrocyclization of ribosomal peptides is a major …

Dehydroamino acid residues in bioactive natural products

S Wang, K Wu, YJ Tang, H Deng - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

Victorin, the host-selective cyclic peptide toxin from the oat pathogen Cochliobolus victoriae, is ribosomally encoded

SC Kessler, X Zhang, MC McDonald… - Proceedings of the …, 2020 - National Acad Sciences
The necrotrophic fungal pathogen Cochliobolus victoriae produces victorin, a host-selective
toxin (HST) essential for pathogenicity to certain oat cultivars with resistance against crown …

The Venturia inaequalis effector repertoire is dominated by expanded families with predicted structural similarity, but unrelated sequence, to avirulence proteins from …

M Rocafort, JK Bowen, B Hassing, MP Cox, B McGreal… - BMC biology, 2022 - Springer
Background Scab, caused by the biotrophic fungus Venturia inaequalis, is the most
economically important disease of apples worldwide. During infection, V. inaequalis …

Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi

SC Kessler, YH Chooi - Natural Product Reports, 2022 - pubs.rsc.org
Covering up to June 2021 Ribosomally synthesized and post-translationally modified
peptides (RiPPs) from fungi are an underexplored class of natural products, despite their …