Accurate DNA replication and repair is essential for proper development, growth and tumor-
free survival in all multicellular organisms. A key requirement for the maintenance of …

RNA interference (RNAi), an accurate and potent gene-silencing method, was first
experimentally documented in 1998 in Caenorhabditis elegans by Fire et al., who …

Six chalcones from Angelica keiskei KOIDZUMI (Ashitaba in Japanese) and two chalcones
from Humulus lupulus L.(hop) were examined for their cytotoxicity in two human …

Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of
the vast majority remains unclear. Here, we show that a p53-regulated lncRNA which we …

A combination of chemical genetic and biochemical assays was applied to investigate the
mechanism of action of the anticancer drug 5-fluorouracil (5-FU), against Mycobacterium …

Epithelial adhesion molecule (EpCAM) is a transmembrane glycoprotein involved in
intercellular adhesion. In particular, EpCAM appears to be overexpressed by the majority of …

Continuous exposure to cisplatin can induce drug resistance to limit efficacy; however, the
underlying mechanisms correlated with cisplatin resistance are still unclear. Drug-sensitive …

The serine/threonine kinase or the so-called “Akt” is a key regulatory molecule of signaling
pathway that regulates various cellular processes. Many intracellular proteins are involved …

Although the deregulated expression of p53R2, a p53-inducible protein and homologue of
the R2 subunit of ribonucleotide reductase, has been detected in several human cancers …

Triple-negative breast cancers (TNBCs) are defined as tumors that lack expression of
estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 …