Synthetic Biology of Natural Products Engineering: Recent Advances Across the Discover–Design–Build–Test–Learn Cycle
Advances in genome engineering and associated technologies have reinvigorated natural
products research. Here we highlight the latest developments in the field across the discover …
products research. Here we highlight the latest developments in the field across the discover …
Design strategy and preliminary antiproliferative investigation of a modified lignan skeleton derived from aryne and statin
Y Lei, Y Wen, X Xu, Q Hu, M Chang… - Organic & Biomolecular …, 2024 - pubs.rsc.org
The biological activities of natural products (NPs) provided precious resources for the
development of new drugs. Numerous studies have shown that statins exhibit cytotoxic …
development of new drugs. Numerous studies have shown that statins exhibit cytotoxic …
Rapid Identification of γ-Butyrolactone Signalling Molecules in Diverse Actinomycetes Using Resin-Assisted Isolation and Chemoenzymatic Synthesis
Y Kudo, K Konoki, M Yotsu-Yamashita - 2024 - chemrxiv.org
Actinomycetes are prolific producers of secondary metabolites with diverse chemical
structures and bioactivities. Secondary metabolism in actinomycetes is regulated by …
structures and bioactivities. Secondary metabolism in actinomycetes is regulated by …
Structural and Biochemical Investigation of an Unusual Biosynthetic Gene Cluster
M Rankin - 2024 - deepblue.lib.umich.edu
Bacteria manufacture a diverse range of natural products with pharmaceutical value as
potent antibiotics and chemotherapeutic agents, many of which are FDA-approved. Two well …
potent antibiotics and chemotherapeutic agents, many of which are FDA-approved. Two well …