Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

Basic and clinical research accomplished during the last few years on embryonic, fetal,
amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in …

Recent advances in human pluripotent stem cell (hPSC) differentiation protocols have
generated insulin-producing cells resembling pancreatic β cells. While these stem cell …

Pancreatic insulin-producing β-cells have a long lifespan, such that in healthy conditions
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …

Of paramount importance for the development of cell therapies to treat diabetes is the
production of sufficient numbers of pancreatic endocrine cells that function similarly to …

Mesenchymal stem cells (MSCs) have been widely used for regenerative therapy. In most
current clinical applications, MSCs are delivered by injection but face significant issues with …

Novel strategies in diabetes therapy would obviously benefit from the use of beta (β) cell
stem/progenitor cells. However, whether or not adult β cell progenitors exist is one of the …

The p16INK4a tumour suppressor accumulates in many tissues as a function of advancing
age,,. p16INK4a is an effector of senescence, and a potent inhibitor of the proliferative …

Multipotent stem/progenitors are present in peribiliary glands of extrahepatic biliary trees
from humans of all ages and in high numbers in hepato‐pancreatic common duct, cystic …

The mechanisms that regulate pancreatic β cell mass are poorly understood. While
autoimmune and pharmacological destruction of insulin-producing β cells is often …