More than just a barrier: using physical models to couple membrane shape to cell function

F Frey, T Idema - Soft matter, 2021 - pubs.rsc.org
The correct execution of many cellular processes, such as division and motility, requires the
cell to adopt a specific shape. Physically, these shapes are determined by the interplay of …

Clathrin coats partially preassemble and subsequently bend during endocytosis

M Mund, A Tschanz, YL Wu, F Frey, JL Mehl… - Journal of Cell …, 2023 - rupress.org
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …

Actin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges

C Yang, P Colosi, S Hugelier, D Zabezhinsky… - Nature …, 2022 - nature.com
Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

Binding of curvature-inducing proteins onto biomembranes

H Noguchi - International Journal of Modern Physics B, 2022 - World Scientific
In this paper, we review the theoretical analyses and simulations of the interactions between
curvature-inducing proteins and biomembranes. Laterally isotropic proteins induce spherical …

Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis

TJ Nawara, YD Williams, TC Rao, Y Hu, E Sztul… - Nature …, 2022 - nature.com
Clathrin polymerization and changes in plasma membrane architecture are necessary steps
in forming vesicles to internalize cargo during clathrin-mediated endocytosis (CME) …

Effective cell membrane tension protects red blood cells against malaria invasion

H Alimohamadi, P Rangamani - PLOS Computational Biology, 2023 - journals.plos.org
A critical step in how malaria parasites invade red blood cells (RBCs) is the wrapping of the
membrane around the egg-shaped merozoites. Recent experiments have revealed that …

Binding of anisotropic curvature-inducing proteins onto membrane tubes

H Noguchi, C Tozzi, M Arroyo - Soft Matter, 2022 - pubs.rsc.org
Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have
anisotropic shapes and anisotropically bend biomembranes. Here, we report how the …

Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosis

RH Anderson, KA Sochacki, H Vuppula, BL Scott… - Cell reports, 2021 - cell.com
Clathrin-mediated endocytosis (CME) is critical for cellular signal transduction, receptor
recycling, and membrane homeostasis in mammalian cells. Acute depletion of cholesterol …

Vesicle budding induced by binding of curvature-inducing proteins

H Noguchi - Physical Review E, 2021 - APS
Vesicle budding induced by protein binding that generates an isotropic spontaneous
curvature is studied using a mean-field theory. Many spherical buds are formed via protein …

Effects of nanoparticle size and shape in clathrin-mediated endocytosis

W Xu, X Liu, X Liu - Journal of Applied Physics, 2022 - pubs.aip.org
Nanoparticles have been extensively adopted to deliver therapeutic drug molecules to cells
through clathrin-mediated endocytosis (CME). The size and shape of nanoparticles are …