▪ Abstract Nitric oxide (NO) regulates numerous physiological processes, including
neurotransmission, smooth muscle contractility, platelet reactivity, and the cytotoxic activity of …

Sepsis is a heterogeneous class of syndromes caused by a systemic inflammatory response
to infection. Septic shock, a severe form of sepsis, is associated with the development of …

Proinflammatory cytokines depress myocardial contractile function by enhancing the
expression of inducible NO synthase (iNOS), yet the mechanism of iNOS-mediated …

Free radicals have been implicated in the etiology of cardiac dysfunction during sepsis, but
the actual species responsible remains unclear. We studied the alterations in myocardial …

The aim of this work was to determine if the inhibition or stimulation of NO synthesis
modulates liver damage induced by the chronic administration of CCl4. CCl4 was …

The societal impact of obesity, diabetes, and other metabolic disorders continues to rise
despite increasing evidence of their negative long-term consequences on health span …

We recently reported that following a toxic dose of acetaminophen to mice, tyrosine nitration
occurs in the protein of cells that become necrotic. Nitration of tyrosine is by peroxynitrite, a …

Nitric oxide (NO) has been established as an important messenger molecule in various
steps of brain physiology, from development to synaptic plasticity, learning and memory …

Background. Although inhibition of endothelial nitric oxide synthase (eNOS) has been
reported to aggravate hepatic ischemia-reperfusion (I/R) injury, the role of inducible nitric …

OBJECTIVES This study was designed to examine the effects of pimobendan in a murine
model of viral myocarditis in relation to proinflammatory cytokine production and nitric oxide …