Metal complexes are extensively used for cancer therapy. The multiple variables available
for tuning (metal, ligand, and metal–ligand interaction) offer unique opportunities for drug …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Platinum-based anticancer drugs have been widely applied in clinical settings for more than
40 years. The remarkable breakthroughs that have come from the use of these complexes in …

The development of organometallic catalysis has greatly expanded the synthetic chemist
toolbox compared to only exploiting “classical” organic chemistry. Although more widely …

Selective activation of prodrugs within a tumor is particularly attractive because of their low
damage to normal tissue. Here, we report the design, photoactivation mechanism, and …

Boronic acid (or ester) is a well-known temporary masking group for developing anticancer
prodrugs responsive to tumoral reactive oxygen species (ROS), but their clinic application is …

Hydrogenation reactions in biology are usually carried out by enzymes with nicotinamide
adenine dinucleotide (NAD (P) H) or flavin mononucleotide (FAMH2)/flavinadenine …

Activation of metalloprodrugs or prodrug activation using transition metal catalysts
represents emerging strategies for drug development; however, they are frequently …

Pd-catalyzed bioorthogonal bond cleavage reactions are widely used and frequently
reported. It is circumscribed by low reaction efficiency, which may encumber the therapeutic …

Recent advances in bioorthogonal catalysis promise to deliver new chemical tools for
performing chemoselective transformations in complex biological environments. Herein, we …