Shikimic acid is a natural product of industrial importance utilized as a precursor of the
antiviral Tamiflu. It is nowadays produced in multihundred ton amounts from the extraction of …

Abstract Fungal laccases (EC 1.10. 3.2) are multi-copper oxidases that oxidize a wide
variety of substrates. Despite extensive studies, the molecular basis for their diverse activity …

Herein, we report computational and experimental evaluations of the antimicrobial activity of
twenty one 2, 3-diaryl-thiazolidin-4-ones. All synthesized compounds exhibited an …

Tuberculosis is a highly infectious disease other than HIV/AIDS and it is one of the top ten
causes of death worldwide. Resistance development in the bacteria occurs because of …

Background: Benzothiazole derivatives are known for anti-TB properties. Based on the
known anti-TB benzothiazole pharmacophore, in the present study, we described the …

Alzheimer's disorder is one of the most common worldwide health problems, and its
prevalence continues to increase, thereby straining the healthcare budgets of both …

Acinetobacter baumannii, an opportunistic pathogen, has become multi-drug resistant
(MDR) to major classes of antibacterial and poses grave threat to public health. The current …

In this study, we describe the development of new machine learning models to predict
inhibition of the enzyme 3‐dehydroquinate dehydratase (DHQD). This enzyme is the third …

The development of new anti-TB drugs to prevent the spread of multidrug-resistant
Mycobacterium tuberculosis (Mtb) strains is imperative. Mtb shikimate kinase (MtSK) was …

Multidrug resistant Mycobacterium tuberculosis (MDR-MTB) infections have created a critical
health problem globally. The appalling rise in drug resistance to all the current therapeutics …