A Comprehensive Review of Andrographis paniculata (Burm. f.) Nees and Its Constituents as Potential Lead Compounds for COVID-19 Drug Discovery

A Intharuksa, W Arunotayanun, W Yooin, P Sirisa-Ard - Molecules, 2022 - mdpi.com
The COVID-19 pandemic has intensively disrupted global health, economics, and well-
being. Andrographis paniculata (Burm. f.) Nees has been used as a complementary …

[PDF][PDF] Andrographis paniculata: a review of pharmacological activities and clinical effects

S Akbar - Alternative Medicine Review, 2011 - altmedrev.com
Andrographis paniculata is a plant that has been effectively used in traditional Asian
medicines for centuries. Its perceived “blood purifying” property results in its use in diseases …

Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

WW Chao, BF Lin - Chinese medicine, 2010 - Springer
Abstract Andrographis paniculata (Burm. f.) Nees (Acanthaceae) is a medicinal plant used in
many countries. Its major constituents are diterpenoids, flavonoids and polyphenols. Among …

Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases:“reverse pharmacology” and “bedside to bench” approach

B B. Aggarwal, S Prasad, S Reuter… - Current drug …, 2011 - benthamdirect.com
Inflammation, although first characterized by Cornelius Celsus, a physician in first Century
Rome, it was Rudolf Virchow, a German physician in nineteenth century who suggested a …

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: Updates and future directions

H Khan, M Reale, H Ullah, A Sureda, S Tejada… - Biotechnology …, 2020 - Elsevier
The anticancer effects of polyphenols are ascribed to several signaling pathways including
the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent …

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

MT Islam, ES Ali, SJ Uddin, MA Islam, S Shaw, IN Khan… - Cancer letters, 2018 - Elsevier
The diterpene lactone andrographolide, isolated from Andrographis paniculata, has been
proven to possess several important protective biological activities, including antioxidant …

Anticancer potential of andrographolide from Andrographis paniculata (Burm. f.) Nees and its mechanisms of action

Z Malik, R Parveen, B Parveen, S Zahiruddin… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Synthetic drugs used for cancer treatment have side
effects that may be immunosupressive, can cause liver, kidney and cardiac toxicity, and …

Natural agents targeting mitochondria in cancer

S Mani, G Swargiary, KK Singh - International journal of molecular …, 2020 - mdpi.com
Mitochondria are the key energy provider to highly proliferating cancer cells, and are
subsequently considered one of the critical targets in cancer therapeutics. Several …

Inhibition of tumor progression by naturally occurring terpenoids

G Kuttan, P Pratheeshkumar, KA Manu… - Pharmaceutical …, 2011 - Taylor & Francis
Context: Cancer is a major public health problem in India and many other parts of the world.
Its two main characteristics are uncontrolled cell growth and metastasis. Natural products …

Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer

P Sharma, T Shimura, JK Banwait, A Goel - Carcinogenesis, 2020 - academic.oup.com
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality in
the USA. As much as 50–60% of CRC patients develop resistance to 5-fluorouracil (5FU) …